Wagener, South Carolina presents an exceptional short-term rental investment opportunity driven by its strategic positioning between Augusta, Georgia and Columbia, South Carolina, creating consistent demand from business travelers, medical professionals visiting nearby healthcare facilities, and tourists exploring the Central Savannah River Area. Property owners can capitalize on occupancy rates averaging 65-75% annually, with daily rates ranging from $85-$150 depending on property size and amenities, translating to potential gross revenues of $20,000-$35,000 per year for well-positioned properties. The town's proximity to Aiken's equestrian events, Lake Murray recreational activities, and Augusta's Masters Tournament generates predictable seasonal spikes that can command premium pricing of 150-200% above standard rates during peak periods. With median home prices remaining below $180,000 and minimal local competition in the short-term rental space, investors can achieve cash-on-cash returns exceeding 12-18% while benefiting from South Carolina's favorable tax environment and lower operational costs compared to saturated markets in Charleston or Greenville.