Oxford, North Carolina presents exceptional short-term rental investment opportunities driven by its strategic proximity to the Research Triangle Park, Raleigh-Durham International Airport, and major universities including Duke and UNC, creating consistent demand from business travelers, visiting academics, and families attending university events. Property owners can capitalize on occupancy rates averaging 65-75% annually with daily rates ranging from $120-180 for well-appointed properties, generating potential gross revenues of $28,000-48,000 per year compared to traditional long-term rental yields of $12,000-18,000 annually. The market benefits from limited hotel inventory in the immediate area, positioning short-term rentals to capture overflow demand from nearby Durham and Chapel Hill, while Oxford's historic charm and lakefront properties on Kerr Lake command premium pricing during peak seasons. With median property acquisition costs remaining 30-40% below comparable markets in the Triangle region, investors can achieve cash-on-cash returns of 12-18% while building equity in an appreciating market that has seen 8-12% annual property value growth over the past three years.